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Kids with obstructive sleep apnea who are dealt with with codeine for submit-tonsillectomy and/or adenoidectomy ache may very well be specifically sensitive to its respiratory depressant impact; on account of threat of life-threatening respiratory melancholy and Demise: codeine is contraindicated in all young children young than twelve several years of age; It's also contraindicated for put up-operative management in pediatric patients young than eighteen several years of age next tonsillectomy and/or adenoidectomy
artemether/lumefantrine will raise the amount or outcome of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Check.
benzhydrocodone/acetaminophen and codeine both boost sedation. Prevent or Use Alternate Drug. Restrict use to sufferers for whom different remedy possibilities are inadequate
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buprenorphine transdermal and codeine equally boost sedation. Keep away from or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
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To see formulary facts to start with create a list of plans. Your list will likely be saved and will be edited Anytime.
Codeine is contraindicated in sufferers who are regarded to become ultrafast CYP2D6 metabolisers: Codeine is transformed in its active metabolite morphine from the hepatic isoenzymes CYP2D6, a few of which exist with genetic click here polymorphisms.
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